Cosmetic Dermatology and Hair Care

Background: Adipose derived stem cells have been shown to have multiple regenerative properties including accelerated wound healing. Stem cells are harvested, purified and cultured to provide an adequate cellular yield. This isolation process required large financial contributions, trained laboratory staff, intensive procedure utilizing multiple purification solutions and expensive equipment. The aim of the study was to investigate the effect of simple lipo-aspirate on wound healing without stem cell cultivation, thereby reducing the cost but still maintaining the adipose stem cell advantage. Methodology: This is a prospective, interventional animal study to investigate the effect of lipo-aspirate on wound healing. Histological evaluation will be discussed. Results: Evaluation shows accelerated wound healing with the treatment of adipose tissue compared to control wounds. Wound healing markers such as epidermal growth, new vessel formation, new collagen formation was all statistically significantly increased. The bacteriology results showed no significant differences and fat treated wounds had a clear histological advantage compared to control wounds. From the histological analysis it appears that fat changes the architecture of the underlying dermis. Analyzing the before and after pictures of patients having received facial fat fills shows the textural changes seen with facial fat fills in facial rejuvenation. 30-50 patients will be discussed as well as management of associated complicates. Conclusion: Facial fat fills aid facial rejuvenation in a process like lipo-assisted wound healing as shown in an animal model.