Sienna Gerdeman (Student Of Gabriella Baki)
University of Toledo, USA
Title: Formulation and evaluation of antibacterial creams and gels containing metal ions for topical application
Biography
Biography: Sienna Gerdeman (Student Of Gabriella Baki)
Abstract
Background: Skin infections occurs commonly and often present therapeutic challenges to practitioners due to the growing concerns regarding multidrug-resistant bacterial, viral and fungal strains. The antimicrobial properties of zinc sulfate and copper sulfate are well known and have been investigated for many years. However, the synergistic activity between these two metal ions as antimicrobial ingredients has not been evaluated in topical formulations.
Objective: The aims of the present study were to formulate topical creams and gels containing zinc and copper alone or in combination and to evaluate the physicochemical properties of the formulations and in vitro antibacterial activity in the formulations.
Methods: Formulation of the gels and creams was followed by evaluating their organoleptic characteristics, physicochemical properties and in vitro antibacterial activity against Escherichia coli and Staphylococcus aureus.
Results: Zinc sulfate and copper sulfate had a strong synergistic antibacterial activity in the creams and gels. The minimum effective concentration was found to be 3 w/w% for both active ingredients against the two tested microorganisms.
Conclusions: This study evaluated and confirmed the synergistic in vitro antibacterial effect of copper sulfate and zinc sulfate in a cream and two gels.