Day 1 :
Keynote Forum
Philippe Benech
Genex Laboratory, France
Keynote: Skin processes in the light of integrative biology
Time : 09:30 - 10:00
Biography:
Philippe Benech has completed his PhD from the Weizmann Institute of Science and postdoctoral studies from Harvard Medical School. He is director of research at the National Center for Scientific Research and is the recipient of several grants and awards. He was considered as a pioneer in the discovery of cytokine signaling pathways and developed Predict Search, a text mining-based software dedicated to the interpretation of transcriptomic data. Founder of several biotechnology companies, he is presently CSO at the GENEX Laboratory devoted to cosmetogenomic analyses.
Abstract:
In the last few years, use of omics technologies has contributed to increase our knowledge in a wide range of skin processes.rnIn particular, DNA microarrays is a powerful tool to identify hundreds of genes and assigning genes into functional networks remains an important challenge.The modulation of a given gene is not by itself sufficient for understanding. Genes function in an orchestrated manner and their products may participate in distinct pathways. Regulatory mechanisms are complex and integrate positive and negative feedback loops, which may cloud and overshadow the global cellular impact. Moreover, whether the gene expression changes are result or causative of a pathological or physiological condition is difficult to determine. In both cases, the difficulty relies on the involvement of protective processes triggered by the cells in response to an alteration.Another issue concerns the analyses of transcriptomic data from skin biopsies of different donors. Whereas the available statistical tools lead to determine common features among different groups, they tend to smooth the overall data to a point where the selected values will detect only the “tip of the iceberg”. Indeed, expression values among similar groups may not vary“by chance” but reflect, along with other subtle changes, specific features of one given donor. Rescuing genes from the “bottom of the iceberg” should provide a better stratification paving the way for personalized skin care, early diagnosis and development of targeted therapies.In the present talk, these different issues will be illustrated through several case studies
Keynote Forum
Sung Tack Kwon
Seoul National University Hospital, South Korea
Keynote: Surgical options for the treatment of Melanoma
Time : 10:00 - 10:30
Biography:
Sung Tack Kwon has been a plastic surgeon as well as a sub-special board certified hand surgeon since 1989 and 2005, respectively. He has worked as a professorrnat Seoul National University since 1996 after the completion of the fellowship at the Hand Center of Thomas Jefferson University Hospital in 1995. As a handrnsurgeon he devoted himself to congenital hand problems as well as tumors of the hand. He is now the chairman of the department of plastic surgery, college ofrnmedicine, Seoul National University. He is a milestone contributor of the ‘Research Gate’ with only a small number of papers (24) which have been reviewed overrn2000 times and cited 67 times in reputed journals.
Abstract:
Surgical Options for the Treatment of Melanoma: The surgical strategies for the treatment of melanoma have evolved overrnour experience treating 211 patients for the recent 20 years. While most of the features of our patients looked similar tornthose written in textbooks, we discovered some unfamiliar ones in our cases: The irrelevance of resection margin to localrnrecurrence and/or metastasis led us to reduce it gradually down to 2cm in maximum. Even less than 1.5mm excision marginsrnhave been employed for the recent 7 years for the 18 cases of nail complex melanoma, which showed neither recurrencernnor metastasis until now regardless of its depth and size. The morbidity between Stage 3 and 4 was not different. The rolernof prophylactic lymphadenectomy appeared unclear. Rather adjuvant interferon therapy might be effective but its effectrnneeds to be clarified. Still the nature of undiscovered metastasis remains an area to be explored. Therefore, our team nowrnpursues “preservative surgery” which emphasizes the optimal resection followed by functional and cosmetic reconstruction,rnespecially in the hand.
Keynote Forum
Thomas Narsete
Denver Integrated Plastic Surgery, USA
Keynote: Further experiences with permafacial implants for lip augmentation
Time : 10:30-11:00
Biography:
Thomas Narsete, M.D. is a board certified plastic surgeon with 30 years’ experience. He was born in Chicago, and graduated from Notre Dame High School. Afterrnfour years of college, Dr. Narsete graduated from the University of Wisconsin, and then attended medical school. He graduated from Loyola Stritch medical schoolrnin 1974. After four years of surgical residency at the University of Wisconsin, he spent two and one half years in formal plastic surgery fellowship at the Universityrnof New Mexico in Albuquerque, New Mexico.rnDr Narsete practiced in the Albuquerque area for twenty years and then relocated to Texas where he worked in two offices as a plastic surgeon, one in north Dallas,rnand the other in Austin. He specializes in facial cosmetic surgery, mother makeovers, and the treatment of deformed children in third world countries. Dr. Narseternwas involved in the original research of the Permafacial implants (Plano, Texas), and has two of the first publications on their use.
Abstract:
Background: There is an abundance of recent studies on facial cosmetic surgery, but with little emphasis on lip rejuvenation.rnSurgical fillers are commonly used and sometimes in conjunction with lip lifts. Neither of these options addresses long termrnlip fullness.rnObjectives: The author presents the results of a long term study of Permafacial (Surgisil LLC, Plano, Texas) for lip augmentation.rnA previous study was presented on the use of these implants in conjunction with facelift surgery. The present study presents thernresults of the authors first fifty patients.rnMethods: In this study, the results of the authors first 100 implants are presented. These groups of patients were followed for uprnto two years. Implant migration, lip function, implant sensation and patient satisfaction are reviewed.rnResults: Few complications are reported. They include implant migration and revision, size adjustments and removals. Nornextrusions were seen in this patient study, and the patient satisfaction was high.rnComplications: There was a significant migration rate that was initially experienced. A modification in technique reduced thisrnrate over the long term. The Permafacial implants are an effective new device to treat lip volume loss and aging.