Day 1 :
Genex Laboratory, France
Time : 09:30 - 10:00
Philippe Benech has completed his PhD from the Weizmann Institute of Science and postdoctoral studies from Harvard Medical School. He is director of research at the National Center for Scientific Research and is the recipient of several grants and awards. He was considered as a pioneer in the discovery of cytokine signaling pathways and developed Predict Search, a text mining-based software dedicated to the interpretation of transcriptomic data. Founder of several biotechnology companies, he is presently CSO at the GENEX Laboratory devoted to cosmetogenomic analyses.
In the last few years, use of omics technologies has contributed to increase our knowledge in a wide range of skin processes.rnIn particular, DNA microarrays is a powerful tool to identify hundreds of genes and assigning genes into functional networks remains an important challenge.The modulation of a given gene is not by itself sufficient for understanding. Genes function in an orchestrated manner and their products may participate in distinct pathways. Regulatory mechanisms are complex and integrate positive and negative feedback loops, which may cloud and overshadow the global cellular impact. Moreover, whether the gene expression changes are result or causative of a pathological or physiological condition is difficult to determine. In both cases, the difficulty relies on the involvement of protective processes triggered by the cells in response to an alteration.Another issue concerns the analyses of transcriptomic data from skin biopsies of different donors. Whereas the available statistical tools lead to determine common features among different groups, they tend to smooth the overall data to a point where the selected values will detect only the “tip of the iceberg”. Indeed, expression values among similar groups may not vary“by chance” but reflect, along with other subtle changes, specific features of one given donor. Rescuing genes from the “bottom of the iceberg” should provide a better stratification paving the way for personalized skin care, early diagnosis and development of targeted therapies.In the present talk, these different issues will be illustrated through several case studies
Seoul National University Hospital, South Korea
Time : 10:00 - 10:30
Sung Tack Kwon has been a plastic surgeon as well as a sub-special board certified hand surgeon since 1989 and 2005, respectively. He has worked as a professorrnat Seoul National University since 1996 after the completion of the fellowship at the Hand Center of Thomas Jefferson University Hospital in 1995. As a handrnsurgeon he devoted himself to congenital hand problems as well as tumors of the hand. He is now the chairman of the department of plastic surgery, college ofrnmedicine, Seoul National University. He is a milestone contributor of the ‘Research Gate’ with only a small number of papers (24) which have been reviewed overrn2000 times and cited 67 times in reputed journals.
Surgical Options for the Treatment of Melanoma: The surgical strategies for the treatment of melanoma have evolved overrnour experience treating 211 patients for the recent 20 years. While most of the features of our patients looked similar tornthose written in textbooks, we discovered some unfamiliar ones in our cases: The irrelevance of resection margin to localrnrecurrence and/or metastasis led us to reduce it gradually down to 2cm in maximum. Even less than 1.5mm excision marginsrnhave been employed for the recent 7 years for the 18 cases of nail complex melanoma, which showed neither recurrencernnor metastasis until now regardless of its depth and size. The morbidity between Stage 3 and 4 was not different. The rolernof prophylactic lymphadenectomy appeared unclear. Rather adjuvant interferon therapy might be effective but its effectrnneeds to be clarified. Still the nature of undiscovered metastasis remains an area to be explored. Therefore, our team nowrnpursues “preservative surgery” which emphasizes the optimal resection followed by functional and cosmetic reconstruction,rnespecially in the hand.
Denver Integrated Plastic Surgery, USA
Time : 10:30-11:00
Thomas Narsete, M.D. is a board certified plastic surgeon with 30 years’ experience. He was born in Chicago, and graduated from Notre Dame High School. Afterrnfour years of college, Dr. Narsete graduated from the University of Wisconsin, and then attended medical school. He graduated from Loyola Stritch medical schoolrnin 1974. After four years of surgical residency at the University of Wisconsin, he spent two and one half years in formal plastic surgery fellowship at the Universityrnof New Mexico in Albuquerque, New Mexico.rnDr Narsete practiced in the Albuquerque area for twenty years and then relocated to Texas where he worked in two offices as a plastic surgeon, one in north Dallas,rnand the other in Austin. He specializes in facial cosmetic surgery, mother makeovers, and the treatment of deformed children in third world countries. Dr. Narseternwas involved in the original research of the Permafacial implants (Plano, Texas), and has two of the first publications on their use.
Background: There is an abundance of recent studies on facial cosmetic surgery, but with little emphasis on lip rejuvenation.rnSurgical fillers are commonly used and sometimes in conjunction with lip lifts. Neither of these options addresses long termrnlip fullness.rnObjectives: The author presents the results of a long term study of Permafacial (Surgisil LLC, Plano, Texas) for lip augmentation.rnA previous study was presented on the use of these implants in conjunction with facelift surgery. The present study presents thernresults of the authors first fifty patients.rnMethods: In this study, the results of the authors first 100 implants are presented. These groups of patients were followed for uprnto two years. Implant migration, lip function, implant sensation and patient satisfaction are reviewed.rnResults: Few complications are reported. They include implant migration and revision, size adjustments and removals. Nornextrusions were seen in this patient study, and the patient satisfaction was high.rnComplications: There was a significant migration rate that was initially experienced. A modification in technique reduced thisrnrate over the long term. The Permafacial implants are an effective new device to treat lip volume loss and aging.
- Track 1: Aesthetic Medicine
Track 2: Clinical Dermatology
Track 3: Dermatovenereology
Track 4: Skin Cancer And Cosmetic Dermatology
Track 5: Plastic Surgery
Track 6: Cosmetics Procedures
PhotoSonix Medical, USA
Wigner Reserach Institute for Physics, Hungary
Photosonix Medical, USA
Time : 11:15-11:40
Mark Schafer is President of Photosonix Medical, and has served in senior roles for several ultrasonic device companies. He has over 20 peer-reviewed publications, 21 patents, and is a Fellow of the AIUM and the ASA. Mark holds a BSEE from MIT and a PhD from Drexel University. Tessie McNeely is an expert in infectious disease and biofilms. She served in senior scientific roles at Merck, where she earned multiple awards for scientific contributions, and was Principal Scientist for the development of an acne vaccine. She holds a BA from Berea College and a PhD from UNC at Chapel Hill.
Bacteria preferentially grow as colonies surrounded by a complex matrix, together called a biofilm. When bacteria form biofilms, they become extremely difficult to treat because they have a physical barrier and exist in a low metabolic state. Recent data demonstrates that P. acnes, which causes chronic acne, forms biofilms which may contribute to the limited efficacy of existing treatments. PhotoSonix Medical, Inc. has developed CLENS™ (Coincident Light Energy and Non-focused ultrasound), a patented energy-based therapy which synergistically combines light and ultrasound energy to treat chronic acne. Ultrasound energy mechanically stresses P. acnes bacteria, causing them to boost their metabolism and become susceptible to treatment. Therapeutic light targets porphyrin, creating reactive oxygen products which are toxic to bacteria. The combined treatment may also enhance healing because ultrasound increases blood flow and tissue remodeling, and light reduces chronic inflammation. To date, both laboratory and in-vivo studies have been conducted. Laboratory testing on P. acnes biofilms demonstrated that the CLENS combination of light and ultrasound caused 90% and 99.94% cell death following 5 min, and 30 minutes of CLENS exposure respectively. Under the same conditions, erythromycin had minimal bactericidal effect. In-vivo data has shown over 90% reduction in skin surface bacteria in as little as 10 minutes. A reduction in skin bacteria of greater than 90% is a validated surrogate for clinical efficacy. Importantly, efficacy required the simultaneous application of both energies. CLENS may offer a new therapeutic option to chronic acne patients without use of antibiotics.
Wigner Reserach Institute for Physics, Hungary
Title: Fiberscope-An optical fiber laser based, Handheld 3D nonliner microscope system for invivo diagnostic applications in Dermatology and Nanomedicine
Time : 11:40-12:05
Róbert Szipőcs received the M.Sc. degree in electrical engineering at the Technical University of Budapest, Hungary, in 1987 and his Ph.D. degree in physics at the University of Szeged, Hungary, in 2001. From 1987 to 2013, he has been working for the Institute for Solid State Physics and Optics of the Wigner Research Center for Physics of the Hungarian Academy of Sciences. From 1997, he is the managing director of R&D Ultrafast Lasers Ltd. He is the author of nearly 50 articles, and a few patents. His research interests include dispersive properties of optical coatings and fibers, ultrafast solid state and fiber lasers, nonlinear microscopy and its applications in dermatology, neuroscience and nanomedicine. He is a member of the Optical Society of America.
Nonlinear microscopy, such as two-photon excitation fluorescence microscopy (2PEF), and second-harmonic generation (SHG) microscopy is being increasingly used to perform in vivo studies in dermatology. These techniques enable us to investigate the morphology and monitor the physiological process in the skin by the use of femtosecond lasers (such as a broadly tunableTi-sapphire laser) operating in the near-infrared spectral range (680-1060 nm). Recent years brought revolutionary progress in development of femtosecond pulse, all-fiber laser oscillators and amplifiers being suitable for nonlinear microscopy. Fiber lasers are of great interest not only because of their considerably lower price but the ease with which they can be combined with endoscopy, which would greatly increase the utility of nonlinear microscopy for pre-clinical applications and tissue imaging. In our presentation we introduce our novel, handheld nonlinear microscope system named FiberScope comprising a ~2MHz repetiton rate Yb-fiber laser as a pulsed light source for nonlinear imaging. Among others, our novel microscope system is capable of high quality in vivo 3D SHG imaging of the collagene content of murine skin at average power levels as low as ~5 mW, which value is measured directly above the skin. (Note this power level corresponds to that of a laser pointer.) Using SHG imaginging of the collagene, we investigated and followed the effects of obesity on dermal collagen alterations for instance. Additionally, using 2PEF microscopy, we could also visualize and monitor the in vivo the uptake of Alexa Fluor 546 labelled nanomedicine by Langerhans cells for 24 hours.
Clinical Hospital Acibademsistina, Macedonia
Time : 12:05-12:30
Andrej Petrov 44 years old. Dermatologist, Head of Dermatology Dpt. in Acibademsistina Hospital. Medical faculty and specialization in dermatology finished in Skopje and Master Degree at University in Belgrade. Finishing PhD thesis until the end of 2015. Principal investigator in ongoing multicentre study CHS1420-02. Speaking English, French, Italian.
Introduction: Fractional carbon dioxide laser is used in the treatment of many dermatological diseases, as well as in several aesthetic procedures. Main objectives: of the study are: to confirm the efficiency and safety of the fractional CO2 laser in skin renewal, and to check the possibility of having a synergistic effect in patients who besides carbon dioxide laser are treated with PRP /platelet-rich plasma/ too. Material and methods: The study was prospective, case control study and was carried out at the Department of Dermatovenerology, in the period from 2013 - 2015, with total number of 232 patients included in the study. The patients were divided into three groups. The first group (Examined Group 1) included 107 patients treated with fractional CO2 laser (Lutronic eCO2) as month therapy. The second group /Control Group/ covered 100 patients treated with neither laser nor plasma in the same period but subjected to local therapy with drugs or other physio-procedures under the existing protocols for treatment of certain diseases. The third group /Examined Group 2/ treated 25 patients with combined therapy of CO2 laser and PRP in the treatment of facial rejuvenation or treatment of acne scars. Inclusive criteria for entering the study are patients who have one of the following clinical conditions: acne and residual efflorescence of acnes, scars from different backgrounds, stretches, photo damaged skin, hyperpigmentation, xantelasma, syringoma, viral warts. Exclusionary criterion in the study is the use of: oral retinoids in period of 6 months prior to the laser treatment, use of anticoagulation therapy, age under 18, presence of systemic diseases in the patient, using artificial light sources, sauna, during the treatment, use of fillers,, pregnancy andherpes viral skin infections. Patients in the second group (CG) undergone therapeutic modalities depending on the diagnosis of the disease, and according to the existing protocols for certain diseases. For patients with acne scars and patients who undergone rejuvenation, the comparison was made with retinoids, topically applied to the skin. For patients with viral diseases of the skin, comparison was made with standard, the most widely used method for treatment of these diseases – cryotherapy. The results and conclusion: Fractional CO2 laser used in treatment of patients with acne scars, is an effective and safe method that causes statistically significant better effect of the treatment, greater patients’ satisfaction, minimal side effects and statistically better response to the therapy. In the treatment of skin rejuvenation, the laser treatment is effective and safe, causing statistically significant higher satisfaction in relation to the control group of patients. Satisfaction with the treatment in patients undergoing rejuvenation is greater than in any of the examined groups. Fractional carbon dioxide laser is safe to use in treatment of viral diseases of the skin and mucous membranes, condylomas and warts, without distinct side effects and discomfort in the treated patients. However, the effect of the therapy and patients’ satisfaction, and also evaluation by the doctors is statistically lower in relation to the control group of patients. In all three indicative subgroups of the laser examined group (acnes, rejuvenation, viral warts) there are no statistically significant mutual differences in relation to the laser treatment, i.e. it is equally efficient. The combined laser treatment using platelet-rich plasma versus laser monotherapy shows greater cumulative assessment of the effect of applied treatment, but without statistical significance.
Ascension Health- Saginaw Michigan, USA
Time : 12:30-12:55
Dr. Arterbery is a radiation oncologist and graduate of the University of Michigan Medical School. She completed her residency at Memorial Sloan Kettering Cancer Center in Manhattan. She has an interest in skin care and is relationship to damage from cancer treatment and was one of the principals in bringing BIAFINE to the US market from France to treat radiation dermatitis. She has a passion to help women improve and delay the aging process and reduce the risk of cancer through natural cosmetics.
Although sun safety and sunscreen had been promoted since the 1940s, studies have shown insufficient implementation by end users thus decreasing overall and efficacy of the benefit of these products. Dermatologists had been faced with an increasing incidence of skin cancer in the large cohort of high-risk patients with irreversible histories of significant sun damage. Skin cancer in the US is more common than other all other cancers combined. Over 100,000 new cases of melanoma and one million new cases of non-melanoma skin cancers are expected to occur per years. Both types are associated with significant morbidity and high healthcare cost. Chemoprevention is a pharmacological invention that prevents, arrests and reverses carcinogenesis. Primary chemoprevention decreases the risk of malignant cancers and it’s important for high-risk patients. There is an increase interest in skin care products that actually can naturally provide decreased risk of skin cancer or assist in the reversal of the UVA damage. In this talk, we will discuss oral and natural retinoids, statins, fern extracts, botanicals, green tea, resveratrol and antioxidants, flavones and nutraceuticals that can be incorporated into anti-aging products to potentially increase the antimutagenic potential and offer a cosmetic benefit as well as a potential long-term benefit for reduction of skin cancer.
Hollywood Dermatology & Cosmetic Surgery/Hollywood, USA
Time : 14:55-15:20
Dr. Baum has built a reputation as a cosmetic dermatologist by providing leading-edge treatments, dedicated and personalized patient care, and excellent aesthetic results. Dr. Baum is often asked to share her expertise to the English and Spanish-speaking media about the latest advancements in skin care technologies. She has collaborated in several publications, in world re-known dermatological journals and books with her research. Dr. Baum remains committed to the highest standards of patient care and is actively involved in several professional organizations. Dr. Baum is proud to treat patients of all ages and skin types, and has experience in cosmetic, general, surgical and pediatric dermatology. Dr. Baum is a proud alumna of the University of Miami with a Bachelor of Science in neuroscience Summa Cum Laude, received her medical degree from the Nova Southeastern University College of Osteopathic Medicine. Upon graduation, Dr. Baum completed an internship in Westchester Hospital, as well as a residency in dermatology at the NSU COM Larkin Community Hospital, where she was chief resident during her last year. She is married with 2 children, and enjoys spending time with her family.
Background: Cutaneous biopsy sites are often difficult to discern or are frequently misidentified when patients present for treatment of skin cancers. This frustrating situation can lead to delays in treatment and wrong site surgeries. Current methods aiming to prevent this situation are not perfect. Objective: This study seeks to determine the efficacy of ultraviolet-fluorescent tattoos in facilitating the correct identification of suspected nonmelanoma skin cancer biopsy sites. Methods: In this prospective cohort, 51 shave biopsy sites were tattooed with ultraviolet- fluorescent ink in a series of 31 patients suspected of having a cutaneous malignancy. At the time of follow up, the ability of the patient and the physician to identify the correct site with and without ultraviolet illumination of the tattoo was recorded. Visibility of the tattoo was graded before and after treatment. Results: Patients could not positively identify their biopsy site in 35% of cases. In 7% of cases, physicians could not confidently identify the site without the aid of ultraviolet illumination. In conjunction with tattoo illumination, physicians confidently identified the site in 100% of the cases. No adverse events occurred. Conclusion: Ultraviolet-fluorescent tattoos offer a safe and reliable means of accurately marking cutaneous biopsy sites. Keywords: Ultraviolet tattoo; nonmelanoma skin cancer; biopsy site; Mohs micrographic surgery
Huazhong University of Science and Technology, China
Title: Seborrhea dermit; Clinical aspect and therapeutic in the Department of Dermatology of National Hospital, Donka, Conakry, Guinea
Time : 15:20-15:45
Aim: The aim of this study was to investigate the epidemiologic profile, to describe the clinical sign and to evaluate the treatment options. Methodology: It was a prospective study from January to December 2014, respectively. It was carried out using 26 patients for seborrhea dermit. Their ages ranged from 10 to 70 years old, inclusive of young adults. The sex rate (H/F) =0.6, with females being dominant during the study. The frequency of seborrhea dermit was represented at 2.98% of consultation in our department. During the study, the main signs were erythema (42,62%) and squamous (42,62%). The level of the sum of the topography was 3,617. About half of the patients lived with HIV(4,330%). The treatment of seborrhea dermit can be local, general or associated. All the patients received maximum attention during the study and profit from a local treatment was favorable at 7,692%. At the end of the study, an increase in the frequency of the seborrhea dermit was observed, with the advent of HIV.
National Hospital of Donka, Guinea
Title: Studies on the side effects of the depigmentation on the skin in the Department of Dermatology in National Hospital of Donka Conakry (Guinea)
Time : 15:45-16:10
Foulematou Soumah, Master in Dermatology in Tongji medical college of Huazhong university of science and technology , Wuhan China. Her research has focused on Dermatology
The aim of the study was to describe the side effects of the depigmentation on the skin in the Guinean population. It was a retrospective on the cross sectional carry out from January 2012 to December 2014 inclusively. The study was based in the 276 patients admitted in our department .The mean age is 25 years , their age range from 18 to 30 years. The main clinical signs observed was; whitness of the skin (100%), loss of elasticity (87%), acne (35%), Burn of the skin (85%), followed by the squamous erythema (15%), cancer of the skin. The side effects of the depigmentation are numerous, however in the African context especially in the tropical countries, are characterize by the appearance of cancers of the skins.
Maternal and Child Health Care Hospital, Hainan, China
Time : 16:10-16:35
Yan ding working in the Department of Dermatology, Maternal and Child Health Care Hospital of Hainan Province, Haikou 570206, Hainan, China. Her research has focused on Dermatology, Nephrology, Internal Medicine (General Medicine)
One of the major disease manifestations of systemic lupus erythematosus (SLE) is lupus nephritis (LN),and the underlying mechanisms are not yet understood. Epstein-Barr virus (EBV) reactivation was associated with the induction of SLE, with EBV-encoded latent membrane protein1 (LMP1) plays a vital role in this process. Although it was reported that LN was associated with LMP1, most of these results are from patients with ages differed greatly (range, 10-56 years). Given the increased prevalence of EBV infection in young patients, we focused on the association of LN and LMP1 expression in the renal tissues of young patients (range, 6-16 years) in this study. We found that the positive rate of LMP1 in the renal tissues was significantly higher in patients with LN compared with control (P<0.001), which is consistent with the previous reports. The positive rates of LMP1 were similar between the patients of initial onset and relapse, and there was no detectable difference between the patients with and without concurrent infection (P>0.05). However, we reported for the first time about the positive correlation of LMP1 with classification of LN. The proportion of young patients positive for anti‑Sm antibody was significantly higher in the LMP1 positive group compared with the LMP1 negative control (P>0.05). These results indicate that EBV infection in the renal of young patients may lead to the increased severity of LN, and the expression of anti-Sm is likely contributed to this process. Keywords: SLE, LN, EBV, LMP1
Harvard Business School, USA
Terry Henry is a Medical Practice Wellness Integration Consultant with nutraMetrix, supporting hospital systems and a wide spectrum of licensed health professionals, from dermatologists to bariatric surgeons. He is a Certified Meditation Instructor, Reiki Master and graduate of Harvard Business School and Williams College.
Oxidative stress and inflammation have been shown to be both a primary and aggravating cause of skin damage and aging. Oxidative stress, either environmental or intrinsic, may have complex metabolic or subclinical root causes, aggravated by effects of medication, poor diet, malabsorption or poor nutrient retention/bioavailability. It has been shown that free radical damage and Nutrient imbalance can impair skin physiology and accelerate functional decline, if the body’s natural antioxidant defense system And immune function become overwhelmed. We will explore several integrative health & nutrient therapy interventions, and Cosmaceutical advances impacting metabolic/psychophysiological regulation, skin health and resilience, and well as opportunities to optimize patient wellness.
Rejuvee™ Inc., USA
Title: Radio Frequency (RF) - Genuine technology & ultrasound cavitation: How it can improve your patients’ results and fatten your pocketbook
Time : 13:40-14:40
Bojana Matovski - The “Beauty Doctor” holds a Doctor of Medicine from the University of Belgrade, the capital of former Yugoslavia. She has studied with such leading providers as plastic surgeon, Jadran Dondic, Doc.dr.sci.med. Nenad Stepic; Zoran Stojcic, a maxilla-facial surgical specialist who has used Pluton Electronic at the Mayo Clinic; and at Jacksonville University Hospital, as well as with Zarko Borovic of Orea – Special Hospital for Plastic Reconstruction and Aesthetic Surgery. After completing this extensive training, she is internationally certified to educate/ train others in the use of all Pluton Electronics devices which are used in conjunction with hospitals specializing in aesthetic plastic surgery. Her motto at work is “rejuvenate the skin – hold up aging!” Because of her outstanding achievements Worldwide, Who’s Who in American Education 2012-13, recognized her, as Owner, Trainer, and Educator of executives, professionals and entrepreneurs, and in May 2012, the National Association of Professional Women named her Woman of the Year 2012/2013.
3rd Generation Radio Frequency technology is the world’s most advanced Radio Frequency technology. Clinically proven and used successfully by physicians, aestheticians and clinics around the world, it regenerates collagen, tightens and tones the skin, improves the appearance of cellulite and reduces body circumference. Three Polar Technology is used to simultaneously heat deep and superficial layers. This focused, selective deep heating stimulates the body’s natural skin renewal process, tightening existing collagen fibers and augmenting new collagen generation. It also accelerates fat metabolism to cause fat cells to shrink, improving cellulite appearance and treating localized bulges and fat deposits in many areas of the body. Treatment provides immediate visual effect and a long-term result. The immediate visible effects are a smoother, tightened appearance and texture – visible from the very first treatment. The long-term effects of the deep heating accelerate the metabolism of fibroblasts, which produce collage, augmenting new collagen generation. Newest Quadruple Radio Frequency is based on active’s BRF Technology (burst Repetition Frequency), combined with real-time continuous thermal skin monitoring. This technology provides treatment effectiveness and side effect free treatments. Quadro Polar RF is designed to produces skin-tightening: it also removes unwanted fat and toxins. The new treatment is based of two RF effects: Fat cells drainage/breakage and skin rejuvenation and lifting. With RF energy, we can increase the metabolism of the connective tissues and break/shrink the fat cells trapped inside them resulting in a smooth, cellulite free skin. Quadro Polar RF penetration through the skin with a limited influence on the epidermis. The procedure is painless, even pleasant: there is a feeling of warmth. Ultrasound Cavitation - “Liposuction without Liposuction” Cavitation implies the use of an appliance equipped with a hand piece which is placed on the skin, targeting fat deposits, so that the fat cells are dissolved by using special manipulation technique. Over a more or less short period of time, cavitation allows to get amazing results such as the reduction of total removal of cellulite and fat in specific areas. This is exactly what Re-Age offers to its clients.